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The X-age Project to Construct a Chinese Aging Clock
论文题目: The X-age Project to Construct a Chinese Aging Clock
作者: Li, Jiaming; Jiang, Mengmeng; .etc
联系作者: [email protected]
发表年度: 2025
DOI: DOI:10.1038/s43587-025-00935-w
摘要:

The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions.

刊物名称: Nature Aging
论文出处: https://www.nature.com/articles/s43587-025-00935-w
影响因子: 25(2025JIF)
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